Pediatric interstitial lung disease revisited
Identifieur interne : 001F71 ( Main/Exploration ); précédent : 001F70; suivant : 001F72Pediatric interstitial lung disease revisited
Auteurs : Leland L. Fan [États-Unis] ; Robin R. Deterding [États-Unis] ; Claire Langston [États-Unis]Source :
- Pediatric Pulmonology [ 8755-6863 ] ; 2004-11.
English descriptors
- Teeft :
- Abca3, Abca3 mutations, Alveolar hemorrhage, Alveolar hemorrhages, Alveolar macrophages, American thoracic, American thoracic society, Anecdotal success, Autopsy study, Baylor college, Biopsy, Body weight, Broblastic foci, Bronchiolitis, Bronchiolitis obliterans, Bronchoalveolar, Bronchoalveolar lavage, Bronchoalveolar lavage cells, Bronchopulmonary dysplasia, Brosing alveolitis, Brosis, Brotic process, Cellular, Chloroquine treatment, Chronic bronchiolitis, Chronic pneumonitis, Clement, Clinical condition, Clinical features, Clinical presentation, Congenital alveolar proteinosis, Considerable morbidity, Corticosteroid, Corticosteroid treatment, Crit, Desquamative, Diagnostic accuracy, Diagnostic approach, Diagnostic value, Differential diagnosis, Distal airways, Electron microscopy, Function testing, Genetic abnormalities, Genetic defects, Growth factors, Heterogeneous group, Histologic, Histologic appearance, Histologic features, Histologic pattern, Hrct, Hypersensitivity, Hypersensitivity pneumonitis, Idiopathic, Immunocompetent children, Interstitial, Interstitial lung disease, Interstitial lung diseases, Interstitial pneumonia, Interstitial pneumonitis, Invasive studies, Larry nogee, Lavage, Lung, Lung biopsies, Lung biopsy, Lung disease, Lung function, Lung injury, Lung transplantation, Macrophage, Milk proteins, Multicenter collaboration, Multidisciplinary consensus, Murine model, Mutation, National survey, Ndings, Neuroendocrine, Neuroendocrine bodies, Neuroendocrine cells, Newborn period, Noninvasive studies, Nsip, Obliterans, Older children, Open lung biopsy, Original review, Other idiopathic, Parenchymal lung disease, Pediatr, Pediatr pulmonol, Pediatr radiol, Pediatric, Pediatric cases, Pediatric sarcoidosis, Persistent tachypnea, Personal communication, Physical examination, Pild, Pneumonia, Pneumonia lymphoid, Pneumonitis, Poor prognosis, Prospective study, Pulmonary alveolar proteinosis, Pulmonary aspiration, Pulmonary function tests, Pulmonary hemosiderosis, Pulmonary hypertension, Pulmonol, Rare disorders, Recent advances, Recent study, Respir, Respir crit care, Skin tests, Surfactant, Surfactant dysfunction mutations, Surfactant function, Surfactant protein, Surg pathol, Syndrome, Systematic approach, Tachypnea, Texas hospital, Tracheal aspirates, Transthoracic lung biopsy, Unique forms, Unknown etiology, Useful measure, Young children.
Abstract
The spectrum of pediatric interstitial lung disease (PILD) includes a diverse group of rare disorders characterized by diffuse infiltrates and disordered gas exchange. Children with these conditions typically present with tachypnea, crackles, and hypoxemia. Recent advances have been made in the identification of different types of PILD that are unique to infancy. More exciting has been the discovery of genetic abnormalities of surfactant function, now described in both children and adults. A systematic evaluation of the child presenting with diffuse infiltrates of unknown etiology is essential to the diagnosis. Most often, lung biopsy is required. Current treatment options remain less than satisfactory, and morbidity and mortality remain considerable. © 2004 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/ppul.20114
Affiliations:
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Le document en format XML
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<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Abca3</term>
<term>Abca3 mutations</term>
<term>Alveolar hemorrhage</term>
<term>Alveolar hemorrhages</term>
<term>Alveolar macrophages</term>
<term>American thoracic</term>
<term>American thoracic society</term>
<term>Anecdotal success</term>
<term>Autopsy study</term>
<term>Baylor college</term>
<term>Biopsy</term>
<term>Body weight</term>
<term>Broblastic foci</term>
<term>Bronchiolitis</term>
<term>Bronchiolitis obliterans</term>
<term>Bronchoalveolar</term>
<term>Bronchoalveolar lavage</term>
<term>Bronchoalveolar lavage cells</term>
<term>Bronchopulmonary dysplasia</term>
<term>Brosing alveolitis</term>
<term>Brosis</term>
<term>Brotic process</term>
<term>Cellular</term>
<term>Chloroquine treatment</term>
<term>Chronic bronchiolitis</term>
<term>Chronic pneumonitis</term>
<term>Clement</term>
<term>Clinical condition</term>
<term>Clinical features</term>
<term>Clinical presentation</term>
<term>Congenital alveolar proteinosis</term>
<term>Considerable morbidity</term>
<term>Corticosteroid</term>
<term>Corticosteroid treatment</term>
<term>Crit</term>
<term>Desquamative</term>
<term>Diagnostic accuracy</term>
<term>Diagnostic approach</term>
<term>Diagnostic value</term>
<term>Differential diagnosis</term>
<term>Distal airways</term>
<term>Electron microscopy</term>
<term>Function testing</term>
<term>Genetic abnormalities</term>
<term>Genetic defects</term>
<term>Growth factors</term>
<term>Heterogeneous group</term>
<term>Histologic</term>
<term>Histologic appearance</term>
<term>Histologic features</term>
<term>Histologic pattern</term>
<term>Hrct</term>
<term>Hypersensitivity</term>
<term>Hypersensitivity pneumonitis</term>
<term>Idiopathic</term>
<term>Immunocompetent children</term>
<term>Interstitial</term>
<term>Interstitial lung disease</term>
<term>Interstitial lung diseases</term>
<term>Interstitial pneumonia</term>
<term>Interstitial pneumonitis</term>
<term>Invasive studies</term>
<term>Larry nogee</term>
<term>Lavage</term>
<term>Lung</term>
<term>Lung biopsies</term>
<term>Lung biopsy</term>
<term>Lung disease</term>
<term>Lung function</term>
<term>Lung injury</term>
<term>Lung transplantation</term>
<term>Macrophage</term>
<term>Milk proteins</term>
<term>Multicenter collaboration</term>
<term>Multidisciplinary consensus</term>
<term>Murine model</term>
<term>Mutation</term>
<term>National survey</term>
<term>Ndings</term>
<term>Neuroendocrine</term>
<term>Neuroendocrine bodies</term>
<term>Neuroendocrine cells</term>
<term>Newborn period</term>
<term>Noninvasive studies</term>
<term>Nsip</term>
<term>Obliterans</term>
<term>Older children</term>
<term>Open lung biopsy</term>
<term>Original review</term>
<term>Other idiopathic</term>
<term>Parenchymal lung disease</term>
<term>Pediatr</term>
<term>Pediatr pulmonol</term>
<term>Pediatr radiol</term>
<term>Pediatric</term>
<term>Pediatric cases</term>
<term>Pediatric sarcoidosis</term>
<term>Persistent tachypnea</term>
<term>Personal communication</term>
<term>Physical examination</term>
<term>Pild</term>
<term>Pneumonia</term>
<term>Pneumonia lymphoid</term>
<term>Pneumonitis</term>
<term>Poor prognosis</term>
<term>Prospective study</term>
<term>Pulmonary alveolar proteinosis</term>
<term>Pulmonary aspiration</term>
<term>Pulmonary function tests</term>
<term>Pulmonary hemosiderosis</term>
<term>Pulmonary hypertension</term>
<term>Pulmonol</term>
<term>Rare disorders</term>
<term>Recent advances</term>
<term>Recent study</term>
<term>Respir</term>
<term>Respir crit care</term>
<term>Skin tests</term>
<term>Surfactant</term>
<term>Surfactant dysfunction mutations</term>
<term>Surfactant function</term>
<term>Surfactant protein</term>
<term>Surg pathol</term>
<term>Syndrome</term>
<term>Systematic approach</term>
<term>Tachypnea</term>
<term>Texas hospital</term>
<term>Tracheal aspirates</term>
<term>Transthoracic lung biopsy</term>
<term>Unique forms</term>
<term>Unknown etiology</term>
<term>Useful measure</term>
<term>Young children</term>
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<front><div type="abstract" xml:lang="en">The spectrum of pediatric interstitial lung disease (PILD) includes a diverse group of rare disorders characterized by diffuse infiltrates and disordered gas exchange. Children with these conditions typically present with tachypnea, crackles, and hypoxemia. Recent advances have been made in the identification of different types of PILD that are unique to infancy. More exciting has been the discovery of genetic abnormalities of surfactant function, now described in both children and adults. A systematic evaluation of the child presenting with diffuse infiltrates of unknown etiology is essential to the diagnosis. Most often, lung biopsy is required. Current treatment options remain less than satisfactory, and morbidity and mortality remain considerable. © 2004 Wiley‐Liss, Inc.</div>
</front>
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<region><li>Colorado</li>
<li>Texas</li>
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<name sortKey="Deterding, Robin R" sort="Deterding, Robin R" uniqKey="Deterding R" first="Robin R." last="Deterding">Robin R. Deterding</name>
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